نتایج جستجو برای: Homology modeling

تعداد نتایج: 435099  

Journal: :journal of paramedical sciences 0
mohammad reza abbaszadegan division of human genetics, immunology research center,avicenna research institute, mashhad university of medical sciences (mums),mashhad morteza moghaddasian proteomics research center, shahid beheshti university of medical sciences, tehran mostafa rezaei tavirani proteomics research center, shahid beheshti university of medical sciences, tehran reza raeisossadati proteomics research center, shahid beheshti university of medical sciences, tehran maryam ebrahimi proteomics research center, shahid beheshti university of medical sciences, tehran reza roozafzoon proteomics research center, shahid beheshti university of medical sciences, tehran

as recent advancements in biology shows, the molecular machines specially proteins, rna and complex molecules play the main role of the so called cell functionality. it means a very big part of the system biology is concerned with the interactions of such molecular components. drug industries and research institutes are trying hard to better understand the concepts underlying these interactions...

Journal: :hepatitis monthly 0
mojtaba mortazavi department of biotechnology, institute of science and high technology and environmental sciences, graduate university of advanced technology, kerman, ir iran mohammad zarenezhad gastroenterohepatology research center, shiraz university of medical sciences, shiraz, ir iran; legal medicine research center, legal medicine organization of iran, tehran, ir iran saeid gholamzadeh legal medicine research center, legal medicine organization of iran, tehran, ir iran seyed moayed alavian baqiyatallah research center for gastroenterology and liver diseases, middle east liver disease center, baqiyatallah university of medical sciences, tehran, ir iran mohammad ghorbani department of pathology, school of medicine, fasa university of medical sciences, fasa, ir iran reza dehghani pharmacology department, school of medicine, shiraz university of medical sciences, shiraz, ir iran

conclusions based on the location of detected rccs in the structure of hbv proteins, it was found that these rccs may have a critical role in correct folding of hbv proteins and can be considered as drug targets. the results of this study provide new and deep perspectives about structure of hbv proteins for further researches and designing new drugs for treatment of hbv. results the pfam search...

Journal: :research in molecular medicine 0
leila pirdel faculty of medical sciences, ardabil branch, islamic azad university, ardabil, iran

background: lipophosphoglycan 3 (lpg3) is required for the lpg assembly, a well known virulent molecule. in this study, the lpg3 gene of the lizard and mammalian leishmania species were cloned and sequenced. a three-dimensional structure (3d) for the target sequence was also predicted by comparative (homology) modeling. materials and methods: an optimization pcr amplification was performed on g...

Journal: :reports of biochemistry and molecular biology 0
mohammed zaghlool saeed al-khayyat tel: +983419133408226; fax: +98341 3221671 ammar ghanem ameen al-dabbagh biology department, college of sciences, university of mosul, mosul city, iraq

background: luxi is a component of the quorum sensing signaling pathway in vibrio fischeri responsible for the inducer synthesis that is essential for bioluminescence. methods: homology modeling of luxi was carried out using phyre2 and refined with the galaxyweb server. five models were generated and evaluated by errat, anolea, qmean6, and procheck. results: five refined models were generated b...

Journal: :international journal of advanced biological and biomedical research 2014
seyedeh habibeh hosseini hossein azarnivand mohammad reza naghavi

medicinal use of the opium poppy (papaver somniferum l) has ancient history, but the isolation of morphine was not described until the early nineteenth century. morphine is the most important alkaloid of opium poppy in the last 50 years. in the morphine pathway has been reported to generate morphine in this species, codm has a crucial role as the gene coding the enzyme responsible for demethyla...

Journal: :iranian journal of public health 0
azadeh ebrahim-habibi bagher larijani

modeling and simulation techniques are now widely used alongside with their experimental counterparts in order to complement them, or sometimes to bring first insights into the possible outcome of experiments. “modeling” is a general word that could encompass a wide range of methods that could be applied to a variety of subjects and problems. here, the use of selected molecular modeling methods...

Journal: :the iranian journal of pharmaceutical research 0
amirhossein sakhteman shiraz university of medical sciences bijan zare school of advanced medical sciences and technologies, shiraz university of medical sciences shiraz, iran.

an interactive application, modelface, was presented for modeller software based on windows platform. the application is able to run all steps of homology modeling including pdb to fasta generation, running clustal, model building and loop refinement. other modules of modeler including energy calculation, energy minimization and the ability to make single point mutations in the pdb structures a...

Journal: :journal of arthropod-borne diseases 0
naghmeh poorinmohammad department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran. hassan mohabatkar department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran.

background : the aim of this study was to generate in silico 3d-structure of the envelope protein of ahfv using homology modeling method to further predict its conformational epitopes and help other studies to investigate its structural features using the model. methods : a 3d-structure prediction was developed for the envelope protein of alkhumra haemorrhagic fever virus (ahfv), an emerging ti...

Journal: :Communications in Statistics - Theory and Methods 2019

2013
Andrew J. Bordner Barry Zorman

Computational methods are needed to differentiate the small fraction of missense mutations BLOCKIN BLOCKIN that BLOCKIN BLOCKIN contribute BLOCKIN BLOCKIN to BLOCKIN BLOCKIN disease BLOCKIN BLOCKIN by BLOCKIN BLOCKIN disrupting BLOCKIN BLOCKIN protein BLOCKIN BLOCKIN function BLOCKIN BLOCKIN from BLOCKIN BLOCKIN neutral BLOCKIN BLOCKIN variants. We describe several complementary methods using l...

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